| Biographies |
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| Jaclynn - I am currently in grade 12 at Harry Ainlay High School in Edmonton, Alberta. Next year, I will be going to the University of Alberta in the Faculty of Science. I hope to have a medical career in the future, but I still dream of being a singer/dancer someday. One of my most notable experiences include representing Canada in the 2008 Chinese Bridge Competition in China, and placing sixth out of forty-two teams from around the world. Another notable experience of mine was We day in Vancouver in October 2010, where speakers inspired me to take action as a global citizen. My dream is to travel and to never stop learning about the world and trying to make it a better place. | | Danny - As a Grade 12 students from Harry Ainlay High School in Edmonton, Alberta, I have a variety of interests. In school, I am a member of the Student Council Executive that plans for numerous school events throughout the year. In particular, my current role is to act as a liaison between the school staff and the student body. Additionally, I have been part of the Dance Club for three years. In Grade 12 year, I became an choreographer as well as an instructor, working to create a routine that will be featured in a year end showcase. Also, in the community, my contributions include being a Youth Ambassador for the Canadian Blood Service and a volunteer for the Stollery Childrens Hospital. These valuable experiences have inspired me to pursue a career as a physician. But in the meantime, I am researching cancer physiology in a pediatric lab at the University of Alberta. Though my work is no where near curing cancer, the satisfaction working with like-minded peers and obtaining positive results have definitely created a lasting impression for the years to come. |
| Jaclynn Wong, Danny Huang
O-GlcNAcylation: Suppressing Cancer Progression
| Challenge: | Health | | Category: | Senior | | Region: | Edmonton | | City: | Edmonton, AB | | School: | Harry Ainlay School | | Abstract: | O-GlcNAcylation is a novel post-translational modification that occurs on a very potent cancer-promoting protein called beta-catenin. In our investigation, we have shown that O-GlcNAcylation inversely regulates beta-catenin's nuclear localization, thereby increasing its interaction with E-cadherin at the plasma membrane, and decreasing its interaction with TCF in the nucleus. This hinders cancer progression as cancer cells become more stable and less likely to proliferate. |
| Awards | Value | Challenge Award - Health
Senior
Sponsor: Canadian Institutes of Health Research | $1 000.00 | Excellence Award - Senior
Gold Medal
Sponsor: Youth Science Canada | $1 500.00 | Dalhousie University Faculty of Science Entrance Scholarship
Senior Gold Medallist - $5000 Entrance Scholarship
Sponsor: Dalhousie University, Faculty of Science | $5 000.00 | UBC Science (Vancouver) Entrance Award
Senior Gold Medallist - $4000 Entrance Scholarship
Sponsor: The University of British Columbia (Vancouver) | $4 000.00 | University of Manitoba Entrance Scholarship
Senior Gold Medallist - $5000 Entrance Scholarship
Sponsor: University of Manitoba | $5 000.00 | The University of Western Ontario Scholarship
Gold Medallist - $4000 Entrance Scholarship
Sponsor: University of Western Ontario | $4 000.00 | University of Ottawa Entrance Scholarship
Senior Gold Medallist - $4,000 Entrance Scholarship
Sponsor: University of Ottawa | $4 000.00 | Platinum Award - Best Senior Project
Sponsor: Youth Science Canada | $5 000.00 | Best Project Award
Sponsor: Youth Science Canada | $10 000.00 | | Total | $39 500.00 | |
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