| Biography |
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| My name is Rohan Sethi. I am a Grade 10 student at St. Paul’s High School in Winnipeg, Manitoba. I have a passion for swimming and playing soccer, and recently became a district-level referee. In my spare time, I do volunteer work around the community. Science has always been one of my favourite subjects. Having participated in science fairs at the regional level since I was in Grade 4, I have thoroughly enjoyed the experiences. Irritable bowel syndrome (IBS) is a chronic and debilitating gastrointestinal disorder with a worldwide prevalence of 10-15%. A poor understanding of how IBS develops in individuals has resulted in a lack of definitive diagnostics and treatment. It is well-known that stressful situations can induce sensations of “butterflies” in our stomachs. This common rationale was used to investigate the effects of PTSD on IBS, with an aim to establish a ‘brain-gut axis.’ This could lead to the development of novel diagnostic measures and therapeutics for IBS. I am thankful for the opportunity to present my project and represent my province at the CWSF this year. I would strongly encourage students to pursue their dreams through perseverance and hard work, and discover a world of endless opportunities. |
| Rohan Sethi
The Brain-Gut Axis: IBS-Related Gene Expression in PTSD-Induced Rat Models
| Challenge: | Health | | Category: | Intermediate | | Region: | Manitoba Schools Science Symposium | | City: | Winnipeg, MB | | School: | St. Paul's High School | | Abstract: | IBS is a debilitating gastrointestinal disorder with no definitive diagnostics or cure. This project investigates the effects of PTSD on expression of IBS-related genetic markers in rat models. The subsequent findings establish a neuroenteric relationship between stress and IBS, and reinforce the brain-gut axis. This study could be used to better understand the pathogenesis of IBS, and facilitate development of novel diagnostic measures and therapeutics. |
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