| Biography |
|---|
| My name is James Iansavitchous and I am a grade 11 student attending A.B. Lucas Secondary School. Apart from participating in science fairs, I also regularly write national and international math contests. I enjoy playing chess, and am actively involved in teaching chess to younger kids, organizing tournaments, as well as competing at provincial level competitions myself. In school, I am involved with our HOSA chapter, chess club, and Science Olympics club. Taking concepts learned in the classroom and applying them motivated me to work in a lab setting. With this project, I hope to further investigate effective routes of treatment for n-acetylcysteine in B-ALL. |
| James Iansavitchous
B-ALL Leukemia Treatment: Exploiting Dependency on ROS to Prevent Proliferation
| Challenge: | Health | | Category: | Senior | | Region: | Thames Valley | | City: | London, ON | | School: | A.B. Lucas S.S. | | Abstract: | Investigation of genetic alterations in important antioxidant response and repair pathways in leukemic B-cells revealed a dependency in maintaining a state of oxidative stress. N-acetylcysteine effectively prevented rapid growth of the cells through reactive oxygen species scavenging, a safer mechanism than existing treatments. With established uses in the healthcare system, N-acetylcysteine can be efficiently repurposed for B-cell acute lymphoblastic leukemia treatment. |
| Awards | Value | University of Ottawa Undergraduate Research Scholarship Award
Senior
Sponsor: University of Ottawa, Faculty of Science | $10 000.00 | Excellence Award - Senior
Bronze Medal
Sponsor: Youth Science Canada | | University of Ottawa Entrance Scholarship
Senior Bronze Medallist - $1000 Entrance Scholarship
Sponsor: University of Ottawa | $1 000.00 | Western University Scholarship
Bronze Medallist - $1000 Entrance Scholarship
Sponsor: Western University | $1 000.00 | | Total | $12 000.00 | |
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