| Biographie |
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| Amal is enrolled in the enrichment program at Sir Wilfrid Laurier S.S. Amal enjoys reading, graphic designing, playing floor hockey and piano. Amal has won a few honors/awards in the Gauss Contest (twice), the Canada`s Royal Legion Speech Contest, the Thames Valley Science and Engineering Fair (multiple), and the Sanofi Merit award. Her observation about the fact that almost 99.6% of clinical trials from 2002 to 2012 aimed at reversing or preventing Alzheimer's Disease failed, mostly owing to blood-brain barrier (BBB) penetration issues, and the fact that some antibodies and shuttle peptides exist that can be manipulated as a BBB molecular "Trojan Horse" to ferry a neurovascular medicine across the BBB using receptor mediated transport system paved the way to coin the original idea of her project. |
| Amal Aziz
Developing a Trojan Horse to Treat Alzheimer's Disease
| Défi: | Innovation | | Catégorie: | Intermédiaire | | Région: | Thames Valley | | Ville: | London, ON | | École: | Sir Wilfrid Laurier S.S. | | Sommaire: | A novel class of triple functioning neurovascular medicine could be re-engineered by fusing it with monoclonal antibodies (mAb) to the transferrin receptor (TR) on the BBB. The TRmAb can act as a molecular Trojan horse to ship the fused drugs through the BBB via a receptor-mediated transport system, owing principally to the significantly improved CNS drug transport, to improve the AD phenotype. |
| Prix | Valeur | Prix Jeunesse innovante
Intermédiaire
Sponsor: La Fondation Gwyn Morgan et Patricia Trottier | 750,00 $ | Prix du défi - Innovation
Intermédiaire
Sponsor: Sciences jeunesse Canada | | Prix d'excellence - Intermédiaire
Médaille d'or
Sponsor: Sciences jeunesse Canada | 250,00 $ | Bourse d’études de Western University
Médaillé d’or - Bourse d'admission de 4 000 $
Sponsor: Université Western | 4 000,00 $ | | Total | 5 000,00 $ | |
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