The Effects of Rheum officinale Extract on Tau Aggregation and Pre-Formed Paired Helical Filaments in vitro
Yang (Linda) Liu
Floor Location : S 179 H
Alzheimer's disease is caused by two main proteins that misfold (aggregate) and form abnormal polymers. Beta-amyloid forms extracellular amyloid plaques whereas the intracellular tangles are made from a protein called tau. Examples from other protein aggregation diseases suggest that the reduction of aggregates alleviates the disease. Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is an important component of the rhubarb plant (Rheum officinale). Emodin is a type of Anthraquinone, an organic compound which has demonstrated the ability to inhibit the aggregation of tau. Rhubarb also contains flavonoids which reduce the formation of harmful plaques that build up in the brains of those with Alzheimer's disease. Phenolic acid, another important component, can protect nerve cells from neurotoxicity induced by oxidative stress. In this study, various concentrations of Rheum officinale extract will be applied to tau proteins in vitro in order to inhibit tau aggregation and dissolve pre-formed tangles made from mutant tau protein.