Sweet Poison:An evaluation of aspartame peptide bond stability and novel analogues for PKU patients
Jennifer Campbell
David Thompson
Floor Location : S 194 H

Aspartame, a non-carbohydrate based artificial sweetener commonly found in many food products, has raised controversy concerning whether it is carcinogenic. However, a recent toxicology report has suggested that aspartame shows no significant health concerns for the general population. Nonetheless, individuals afflicted by Phenylketonuria (PKU), a disorder characterized by a deficiency in the enzyme phenylalanine hydroxylase which metabolizes phenylalanine, are advised to avoid consumption of aspartame containing products. The purpose of this project is to design new artificial sweeteners for PKU patients without the health risks associated with aspartame using comprehensive enzymatic studies, nuclear magnetic resonance analysis and quantum chemical calculations.