Clopidogrel vs Aspirin
Arnima Singh
Stratford Hall
Floor Location : M 077 H

With almost 32 million Americans using three or more medicines daily, the budget can be a problem for those with a lower income. (Heart Disease Statistics). The average American makes around 51,939 dollars every year. (Workopolis, Author). Medications are something that despite your tight budget are a necessity to survive. In this experiment, natural and over the counter sugars were found that could replace mannitol which is the binder in a pill called clopidogrel. (75mg Film-Coated Tablets Clopidogrel). Clopidogrel is used to prevent strokes from happening in the present and future. The most expensive ingredient in Clopidogrel is mannitol which is the binding substance. Clopidogrel was chosen because of the sugar-binding substance and the usefulness as well as the cost of the pill. (Clopidogrel: Indications, Side Effects, Warnings) On average one, Clopidogrel pill costs around $4 whereas Aspirin, which serves the same purpose costs around 60 cents per pill. Obviously, those with a tighter budget would choose Aspirin despite the fact that Clopidogrel has been proven multiple times to be superior and more useful than Aspirin. (CLOPIDOGREL vs. ASPIRIN). The goal of the experiment was to find a natural and cheap substitute for mannitol in Clopidogrel to help decrease the overall price while keeping the effectiveness of the pill. (Staff, Mayo Clinic). These substitutes included by not all, glucose powder, honey, mannitol, isomalt etc. The pill was rebound with these natural agents to see if their dissolving time would be faster or not. After the materials were combined with the new binder, they were frozen overnight to form a pill shape. (Staff, Mayo Clinic). The next day, once the pills had solidified, they were dropped one by one into separate beakers of hydrochloric acid (one pill per beaker). This was used to test the effectiveness of the binder, by timing how long it took to dissolve as hydrochloric acid has the same PH level as the human stomach. The hypothesis was that isomalt and honey would be the best binding agents due to the similar structure, cost, and no allergic or medical danger. However, once the experiment had been conducted, the results refuted the hypothesis. Glucose overall maintained the most balanced route no matter how much binder was added which meant that it was a lot stronger. Overall the experiment went well, and the proposed binder is glucose for the pill Clopidogrel. For next time, more materials and ingredients are to be substituted so that a cheaper pill can be made and sold into the market.