Polarity for Prevention
Charm Batilo, Brianna Mei
Ideal Mini School
Floor Location : M 098 H
Our project surrounds the idea of anti-angiogenesis and the naturally occurring substances in food with this property. Anti-angiogenesis inhibits the formation of blood vessels that “feed” cancerous tumours and other diseases. The idea of preventing illness through naturally occurring angiogenic inhibitors was very intriguing, and we believe that this research will be very beneficial for a variety of people, whether they are suffering from cancer or any other angiogenesis induced illness, or just interested in integrating anti-angiogenic foods in their diets for the sake of prevention.
In our experiment, we compared lycopene and green tea catechin to see which anti-angiogenic substance was capable of passing through cell membranes more efficiently. We used Paper Chromatography to determine which substance was more non-polar, and therefore would be able to freely pass by passive transport into a cell.
Through our experiment, we learned that Lycopene was more non-polar since its retardation factor was revealed to be higher than that of Catechin. Although this did not support our hypothesis, we learned that different anti-angiogenic properties can be more efficient and beneficial than others. This can be applied to further research to experiment with other naturally occurring anti-angiogenic substances, and new ways to treat and prevent cancer.