Endotoxin's Association With Wheeze and Atopy
Burnaby North Secondary
Floor Location : S 007 H
Asthma and allergy prevalence has been on the rise in Canada and around the world since the 20th century. Currently, a paradox is present regarding whether household dust endotoxin exposure in childhood administers a protecting or exacerbating effect on asthma and allergy development, as the present literature has reached contradictory conclusions on this controversial subject. The design of this research centers around the analysis of data extracted from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, which this research will analyze using regression modelling and significance testing to better understand what relationship, if any, endotoxin has on our outcomes of interest. The CHILD data regarding household endotoxin levels and outcomes of wheeze and atopy at 3 years of age were tested for significance against logged endotoxin levels and were controlled for covariates in an adjusted logistics regression model to determine whether logged endotoxin concentrations had an association with the outcomes. After analysis, all the odds ratios indicated that endotoxin may provide a protective effect on all outcomes; however, this cannot be stated with absolute certainty, due to a lack of statistical significance in models adjusting for other factors that may influence our exposure and disease. Further research regarding the impact of the age of endotoxin exposure on outcomes, as well as the microbial composition of household dust and its predictors is currently needed.