BandaGEL - A Phytochemical- Based Liquid Bandage
Pari Goyal
David Thompson Secondary
Floor Location : M 039 N

Introduction and Rationale:
The purpose of this project was to compare the effects of BandaGEL, a phytochemical-based liquid bandage and Flamazine 1% cream on bacterial growth. The effectiveness of both applications was analyzed and tested to determine which is able to inhibit or prevent the growth of the bacteria and reduce infections. Staphylococcus aureus is a commensal bacterium known to colonize the human skin. However, it is capable of causing various infections such as secondary skin infection of wounds, impetigo, and in several cases, cellulitis. In the case of infectious wounds, an effective bandage covering is crucial to manage the infection and prevent further spread. This is particularly important in a hospital setting to prevent the spread of infection to other patients and workers. Pus from an infected site is very infectious, namely from antibiotic-resistant s. aureus (MRSA) and thus, a highly effective bandage, like BandaGEL becomes critical.

Methods:
The phytochemical-based liquid bandage is a combination of curcumin, azadirachtin, and naringenin, derived from natural sources mixed with a hydrogel-like substance. These three natural substances make this liquid bandage antiseptic, and capable of killing and preventing the growth of bacteria. The Flamazine 1% cream is a sterile white cream with silver sulfadiazine as an active ingredient. It is a topical antibacterial cream commonly used to help prevent and treat wound infections and burns. The phytochemical-based liquid bandage (BandaGEL) and Flamazine 1% cream were tested on samples of s. aureus collected from various surfaces. Bacterial growth was then examined after certain periods of time (t=0, t=24 hours) in order to assess their effectiveness.

Results:
The efficacy of both methods was evaluated using naked-eye comparisons. ‘Manual counting’ was one method used, whereby areas of BandaGEL and Flamazine 1% cream application were compared. In the areas where the medications were not applied, there was a significant increase in the number of staph bacteria colonies (10-20 colonies). The areas with the applications prevented the growth of bacteria. Another method used was the ‘Zone of Inhibition’ test and a clear difference can be seen in how the bacterial colonies appear. In areas of bacterial growth where both methods were applied, a zone of inhibition can be seen. This clearly demonstrates the antiseptic properties of both applications. At t= 24 hours the effects of both the liquid bandage and Flamazine 1% cream were similar in appearance.

Conclusion:
Overall, the liquid bandage and the Flamazine 1% cream had similar efficacy in reducing bacterial colonies. However, the phytochemical-based liquid bandage and the Flamazine 1% cream differ in many ways. BandaGEL is completely natural without any extra chemicals, has a long shelf-life, is cost-effective, and has very similar efficacy to the Flamazine 1% cream.
Further studies may be required to establish the long-term effects of BandaGEL on bacterial reduction, as well as its potential use in clinical practice.