A Novel Study on the Link Between Negative Thinking and TP53-Mutated Carcinogenesis
Sophia Yang
Prince of Wales Secondary
Floor Location : S 063 H

This study observed the link between negative thinking and carcinogenesis. A study by John Hopkins University revealed two-thirds of all adult cancer cases are caused by ‘random’ genetic mutations that induce tumor growth. This phenomenon gave insight into why those who lead physically healthy lifestyles may still get diagnosed with cancer. The direction this study takes comes from the assumption that there is an underlying influence causing these ‘random’ genetic mutations. The hypothesis for this project is that negative thinking patterns can lead to mutation in the TP53 gene, promoting carcinogenesis. A content analysis showed that constant negative thoughts over long​ periods of time can change the way signals are being interpreted in the body and stimulate the release of compounds that prevent genes from producing proteins. Thirty-seven case studies​ revealed that 92.5% of TP53-mutated cancer patients had chronic negativity (>25 weeks) prior to any diagnostics, thus showing the correlation between negative thinking and carcinogenesis. This correlation provides a better understanding of the mystery in these ‘random’ genetic mutations and provides people with information that can help them take preventative measures. This also shows medical innovation involving the mind-body connection such as having a more holistic approach to disease prevention can be beneficial to future patient care.