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CWSF 2011 - Toronto, Ontario

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Jaclynn - I am currently in grade 12 at Harry Ainlay High School in Edmonton, Alberta. Next year, I will be going to the University of Alberta in the Faculty of Science. I hope to have a medical career in the future, but I still dream of being a singer/dancer someday. One of my most notable experiences include representing Canada in the 2008 Chinese Bridge Competition in China, and placing sixth out of forty-two teams from around the world. Another notable experience of mine was We day in Vancouver in October 2010, where speakers inspired me to take action as a global citizen. My dream is to travel and to never stop learning about the world and trying to make it a better place.
Danny - As a Grade 12 students from Harry Ainlay High School in Edmonton, Alberta, I have a variety of interests. In school, I am a member of the Student Council Executive that plans for numerous school events throughout the year. In particular, my current role is to act as a liaison between the school staff and the student body. Additionally, I have been part of the Dance Club for three years. In Grade 12 year, I became an choreographer as well as an instructor, working to create a routine that will be featured in a year end showcase. Also, in the community, my contributions include being a Youth Ambassador for the Canadian Blood Service and a volunteer for the Stollery Childrens Hospital. These valuable experiences have inspired me to pursue a career as a physician. But in the meantime, I am researching cancer physiology in a pediatric lab at the University of Alberta. Though my work is no where near curing cancer, the satisfaction working with like-minded peers and obtaining positive results have definitely created a lasting impression for the years to come.

Jaclynn Wong, Danny Huang

O-GlcNAcylation: Suppressing Cancer Progression
City:Edmonton, AB
School:Harry Ainlay School
Abstract:O-GlcNAcylation is a novel post-translational modification that occurs on a very potent cancer-promoting protein called beta-catenin. In our investigation, we have shown that O-GlcNAcylation inversely regulates beta-catenin's nuclear localization, thereby increasing its interaction with E-cadherin at the plasma membrane, and decreasing its interaction with TCF in the nucleus. This hinders cancer progression as cancer cells become more stable and less likely to proliferate.

Awards Value
Challenge Award - Health
Sponsor: Canadian Institutes of Health Research
$1 000.00
Excellence Award - Senior
Gold Medal
Sponsor: Youth Science Canada
$1 500.00
Dalhousie University Faculty of Science Entrance Scholarship
Senior Gold Medallist - $5000 Entrance Scholarship
Sponsor: Dalhousie University, Faculty of Science
$5 000.00
UBC Science (Vancouver) Entrance Award
Senior Gold Medallist - $4000 Entrance Scholarship
Sponsor: The University of British Columbia (Vancouver)
$4 000.00
University of Manitoba Entrance Scholarship
Senior Gold Medallist - $5000 Entrance Scholarship
Sponsor: University of Manitoba
$5 000.00
The University of Western Ontario Scholarship
Gold Medallist - $4000 Entrance Scholarship
Sponsor: University of Western Ontario
$4 000.00
University of Ottawa Entrance Scholarship
Senior Gold Medallist - $4,000 Entrance Scholarship
Sponsor: University of Ottawa
$4 000.00
Platinum Award - Best Senior Project
Sponsor: Youth Science Canada
$5 000.00
Best Project Award
Sponsor: Youth Science Canada
$10 000.00
Total$39 500.00