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CWSF 2012 - Charlottetown, Prince Edward Island

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My name is Lisa Di Vona and I'm a grade 12 student from Woodbridge, Ontario. I'm involved in many intra and extra-curricular activities such as councils, sports teams, clubs, and more. Throughout the years I have had many memorable experiences such as the Legislative Page Program, U of T summer programs etc. I decided to focus my project in childhood cancer research. Following the choice to sign up for the York Region Science Fair, I found a laboratory in which to complete my project and finalized my project topic. My project focused on drug discovery for the treatment of neuroblastoma, the most common childhood cancer in children under the age of five. This project was successful and resulted in a novel finding, therefore further investigations will occur for publication. If I could give advice to other students it would be to reach for the top and always go for their dreams, because they will be amazed of what they can accomplish.

Lisa Marie Di Vona

Identification of New Aurora Kinase Inhibitors: Treatment of Human Neuroblastoma
City:Woodbridge , ON
School:Father Bressani Catholic H.S.
Abstract:Neuroblastoma, a solid tumor, is caused by uncontrolled/abnormal growth of neuroblasts. The treatment of this tumor depends on the amplification of the MYCN oncogene, indicator of aggressiveness. These experiments were directed to determine if novel Aurora Kinase inhibitors could be used in neuroblastoma treatment. The results showed Aurora Kinase inhibitors induced apoptosis in MYCN-amplified cell lines, which was significantly different in non-MYCN amplified cell lines.

Awards Value
Excellence Award - Senior
Silver Medal
Sponsor: Youth Science Canada
Dalhousie University Faculty of Science Entrance Scholarship
Senior Silver Medallist - $2500 Entrance Scholarship
Sponsor: Dalhousie University, Faculty of Science
$2 500.00
UBC Science (Vancouver) Entrance Award
Senior Silver Medallist - $2000 Entrance Scholarship
Sponsor: The University of British Columbia (Vancouver)
$2 000.00
University of Ottawa Entrance Scholarship
Senior Silver Medallist - $2000 Entrance Scholarship
Sponsor: University of Ottawa
$2 000.00
Western University Scholarship
Silver Medallist - $2000 Entrance Scholarship
Sponsor: Western University
$2 000.00
Total$9 200.00