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CWSF 2015 - Fredericton, New Brunswick

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Lucas Penny is a passionate grade 10 student, scientist and athlete. He has been actively involved with science all of his life. His past scientific work has included researching TrkB, which plays a crucial role in development of brain networks, to study in a mouse model of autism spectrum disorder (ASD). Lucas is also on the rowing team for school. During his grade 9 year, he won gold with his crew in the Canadian National Secondary School Regatta. Aside from athletics, he is a member of the Education Minister’s Student Advisory Council, and is playing level 8 Royal Conservatory of Music. At school, Lucas is the President of the DECA club, a member of the Student Council, and on the committee for Relay for Life. Lucas hopes to pursue a career in medicine and believes that being involved with science fair is an incredible way to contribute to his learning and society at large.

Lucas Penny

Rhomboid Protease 4 mRNA Expression In A Mouse Model of Alzheimer's Disease
City:Grimsby, ON
School:Grimsby S.S.
Abstract:Rhomboid-related protein 4 is a protease that cleaves the Amyloid Precursor Protein (APP). However, mutations in APP follow a separate process to produce toxic Amyloid-β. Excess of Amyloid-β in the brain is one of the primary markers of Alzheimer’s disease. In this study, transgenic APP23 mice that over-express mutated APP were used as a partial model of Alzheimer’s disease to test Rhomboid 4 expression.

Awards Value
Excellence Award - Intermediate
Bronze Medal
Sponsor: Youth Science Canada
Western University Scholarship
Bronze Medallist - $1000 Entrance Scholarship
Sponsor: Western University
$1 000.00
Total$1 000.00