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CWSF 2017 - Regina, Saskatchewan

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Amal is enrolled in the enrichment program at Sir Wilfrid Laurier S.S. Amal enjoys reading, graphic designing, playing floor hockey and piano. Amal has won a few honors/awards in the Gauss Contest (twice), the Canada`s Royal Legion Speech Contest, the Thames Valley Science and Engineering Fair (multiple), and the Sanofi Merit award. Her observation about the fact that almost 99.6% of clinical trials from 2002 to 2012 aimed at reversing or preventing Alzheimer's Disease failed, mostly owing to blood-brain barrier (BBB) penetration issues, and the fact that some antibodies and shuttle peptides exist that can be manipulated as a BBB molecular "Trojan Horse" to ferry a neurovascular medicine across the BBB using receptor mediated transport system paved the way to coin the original idea of her project.

Amal Aziz

Developing a Trojan Horse to Treat Alzheimer's Disease
Region:Thames Valley
City:London, ON
School:Sir Wilfrid Laurier S.S.
Abstract:A novel class of triple functioning neurovascular medicine could be re-engineered by fusing it with monoclonal antibodies (mAb) to the transferrin receptor (TR) on the BBB. The TRmAb can act as a molecular Trojan horse to ship the fused drugs through the BBB via a receptor-mediated transport system, owing principally to the significantly improved CNS drug transport, to improve the AD phenotype.

Awards Value
Youth Can Innovate Awards
Sponsor: The Gwyn Morgan and Patricia Trottier Foundation
Challenge Award - Innovation
Sponsor: Youth Science Canada
Excellence Award - Intermediate
Gold Medal
Sponsor: Youth Science Canada
Western University Scholarship
Gold Medallist - $4000 Entrance Scholarship
Sponsor: Western University
$4 000.00
Total$5 000.00