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CWSF 2017 - Regina, Saskatchewan

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My name is Winnie Xu, and I am a senior at Elgin Park Secondary in Vancouver BC. Although I only realized one of my biggest passions as a junior last year when completing at my first science fair, I immediately knew that scientific research would become a household favorite. This year's project explored the various mechanisms governing the blood brain barrier's strict surveillance. I was intrigued by one of the biggest challenges in drug administration- crossing this barrier without disrupting its regular functions- and decided to investigate further. Beyond my heavy involvement in research, I actively promote scientific literacy and youth innovation as Regional Chair for The Foundation for Student Science and Technology's Ambassador Program, as well as a leader of many other federally registered non-profit organizations. When not wearing close-toed shoes and lab coats, I also really enjoy the permanent damage of pointe shoes and gracing a stage with balletic and contemporary movement. Coming face to face with scientific development had me constantly inspired by the many pioneers in the fields of biotechnology and medicine, and I definitely hope to continue developing my passions and ideas throughout the years to come.

Winnie Xu

Function of Podocalyxin in the Maintenance of the Blood Brain Barrier
Region:South Fraser
City:Surrey, BC
School:Elgin Park Secondary
Abstract:Podocalyxin (Podxl) on vascular endothelial cells maintains the proper morphology and integrity of the blood brain barrier (BBB). During systemic inflammation, its expression is required to maintain structural integrity. To further assess the BBB ultrastructure, a dye tracing assay, transmission electron microscopy (TEM) at cell-cell junctions, and ELISA paracrine factor analyses were completed. These discoveries indicate novel mechanisms involved in maintaining proper physiology during pathogenesis.

Awards Value
Excellence Award - Senior
Silver Medal
Sponsor: Youth Science Canada
Dalhousie University Faculty of Science Entrance Scholarship
Senior Silver Medallist - $2500 Entrance Scholarship
Sponsor: Dalhousie University, Faculty of Science
$2 500.00
UBC Science (Vancouver) Entrance Award
Senior Silver Medallist - $2000 Entrance Scholarship
Sponsor: The University of British Columbia (Vancouver)
$2 000.00
University of Ottawa Entrance Scholarship
Senior Silver Medallist - $2000 Entrance Scholarship
Sponsor: University of Ottawa
$2 000.00
Western University Scholarship
Silver Medallist - $2000 Entrance Scholarship
Sponsor: Western University
$2 000.00
Total$8 500.00