Détails du projet

Effectuez une nouvelle recherche<<Premier  <Précédent [940 de 5967Prochain>  Dernier>>

ESPC 2017 - Regina (Saskatchewan)

Imprimer/Télécharger en format PDF

Amal is enrolled in the enrichment program at Sir Wilfrid Laurier S.S. Amal enjoys reading, graphic designing, playing floor hockey and piano. Amal has won a few honors/awards in the Gauss Contest (twice), the Canada`s Royal Legion Speech Contest, the Thames Valley Science and Engineering Fair (multiple), and the Sanofi Merit award. Her observation about the fact that almost 99.6% of clinical trials from 2002 to 2012 aimed at reversing or preventing Alzheimer's Disease failed, mostly owing to blood-brain barrier (BBB) penetration issues, and the fact that some antibodies and shuttle peptides exist that can be manipulated as a BBB molecular "Trojan Horse" to ferry a neurovascular medicine across the BBB using receptor mediated transport system paved the way to coin the original idea of her project.

Amal Aziz

Developing a Trojan Horse to Treat Alzheimer's Disease
Région:Thames Valley
Ville:London, ON
École:Sir Wilfrid Laurier S.S.
Sommaire:A novel class of triple functioning neurovascular medicine could be re-engineered by fusing it with monoclonal antibodies (mAb) to the transferrin receptor (TR) on the BBB. The TRmAb can act as a molecular Trojan horse to ship the fused drugs through the BBB via a receptor-mediated transport system, owing principally to the significantly improved CNS drug transport, to improve the AD phenotype.

Prix Valeur
Prix Jeunesse innovante
Sponsor: La Fondation Gwyn Morgan et Patricia Trottier
750,00 $
Prix du défi - Innovation
Sponsor: Sciences jeunesse Canada
Prix d'excellence - Intermédiaire
Médaille d'or
Sponsor: Sciences jeunesse Canada
250,00 $
Bourse d’études de Western University
Médaillé d’or - Bourse d'admission de 4 000 $
Sponsor: Université Western
4 000,00 $
Total5 000,00 $